Leonotis leonurus, locally frequently called “wilde dagga”, is generally made use of as a product, both topically and by mouth, in the treatment of a wide range of problems such as haemorrhoids, dermatitis, skin rashes, boils, itching, muscle pains, headache, epilepsy, upper body infections, snake, crawler as well as constipation attacks. The dried out flowers and also fallen leaves are likewise smoked to eliminate epilepsy. The blossoms as well as leaves are reported to produce a mild euphoric result when smoked and also have been stated to have a similar, although much less powerful, psychoactive effect to marijuana. The phytochemistry of specifically the non-volatile components of leonotis leonurus has been thoroughly checked out as a result of rate of interest created as a result of the wide variety of biological effects reported for this plant. Greater than 50 compounds have actually been isolated and characterised. L. leonurus consists of primarily terpenoids, especially labdane diterpenes, the significant diterpene reported is marrubiin. Numerous other substances have been reported by some authors to have actually been isolated from the plant, including, in the preferred literary works only, the gently psychoactive alkaloid, leonurine. Leonurine has nevertheless, never ever been reported by any kind of scientific analysis of the removes of L. leonurus. The typical use by smoking additionally needs more investigation as to how the chemistry as well as task are impacted by this form of administration. Research study has verified the psychedelic effects of the crude essence of L. leonurus, but verification of the existence of psychoactive substances, along with seclusion and characterization, is still called for. Much job is for that reason still required on the element of quality control to ensure security, quality as well as effectiveness of the item provided to patients, as this plant is widely utilized in South Africa as a standard medicine. Commercially offered plant resources provide a sensible option for phytochemical research, particularly when it come to the proper validation of the plant material in order to identify and also delimit carefully associated species such as L. leonurus and also L. nepetifolia which are really comparable in practice.